Bronchiectasis & NTM Research Registry & Biorepository
A growing cohort and biobank of blood, sputum, nasal brushings, and bacterial isolates from a diverse group of adults with bronchiectasis and NTM lung disease, shared with researchers studying these understudied diseases.
Shoshana Zha, MD, PhD · Lung disease
Overview
INTEGRATE launched a prospective cohort and biobank in 2024; about 120 participants have since donated blood. With pipeline funding, the biobank is expanding from the Lung Health Center at Parnassus to the Chest Clinic at Zuckerberg San Francisco General, with a focus on groups underrepresented in research, and adding sputum and nasal brushings alongside blood (PBMCs, serum, plasma), NTM bacterial isolates, and yearly quality-of-life and social-needs questionnaires. The goal is to enroll 75 more participants. Samples support studies of how NTM bacteria and the immune system interact to cause lung disease, new bronchiectasis subtypes in diverse populations, and how CFTR-related disorders affect immune responses to NTM. OCR is helping upgrade sample tracking and the database, and a research website for sample requests is planned.
The collection
- Collection model
- Biobank
- Specimen types
- Blood (PBMCs, serum, plasma)SputumNasal brushingsNTM isolatesQuestionnaires
- Assays and data types
- Macrophage infection modelsSputum transcriptomics and proteomicsAir-liquid interface co-culture
- Participants
- Adults with bronchiectasis and/or NTM lung disease in INTEGRATE clinics, with a focus on groups underrepresented in research
- Disease areas
- BronchiectasisPulmonary NTM
People and partners
- Lead investigator
- Shoshana Zha, MD, PhD
- Department
- Medicine · Pulmonary, Critical Care, Allergy & Sleep Medicine
- Sites
- Parnassus (Lung Health Center); Zuckerberg San Francisco General (Chest Clinic)
- Collaborators
- INTEGRATE (Bronchiectasis & NTM Program); Jon Budzik, MD, PhD; UCSF Airway Clinical Research Center; UCSF Clinical Microbiology Laboratory