Science we're moving forward.
OCR contributes to research across cancer, autoimmunity, infection, lung disease, and critical care. This page shows where, and what that contribution looks like.
Projects are individual research efforts.
One biospecimen collection effort, clinical study, or trial. Some belong to a program; others stand alone.
Some belong to a program.
- PendingClinical trial · Phase 2 · Not yet recruitingAutoimmunity
ALPHA: Modzatinib for Oral Lichen Planus
Kamal Al-Eryani, DDS, PhD
A Phase 2 trial testing modzatinib, an investigational pill that calms overactive T cells, in adults with moderate-to-severe erosive oral lichen planus not controlled by topical treatments. Intervention: Modzatinib (ATI-2138) oral tablet, two dose levels vs. placebo, 16 weeks. Eligibility: Adults 18–75 with biopsy-confirmed, moderate-to-severe erosive oral lichen planus not adequately controlled with topical therapy.
- PendingClinical study · Observational · Not yet recruitingInfectious disease
STRIDE-CAP: CAPVAXIVE Effectiveness Against Pneumonia
Sarah Doernberg, MD, MAS
A Merck study of adults 65 and older hospitalized with pneumonia, comparing vaccination histories to measure how well the CAPVAXIVE vaccine prevents pneumococcal pneumonia. Intervention: None (observational; CAPVAXIVE received only through routine care). Eligibility: Adults 65+ hospitalized with community-acquired pneumonia confirmed by symptoms and chest imaging.
- ActiveBiospecimen collection · BiobankLung disease
Bronchiectasis & NTM Research Registry & Biorepository
Shoshana Zha, MD, PhD
A growing cohort and biobank of blood, sputum, nasal brushings, and bacterial isolates from a diverse group of adults with bronchiectasis and NTM lung disease, shared with researchers studying these understudied diseases. Samples collected: Blood (PBMCs, serum, plasma), sputum, nasal brushings, nTM isolates, questionnaires. Analyses: Macrophage infection models, sputum transcriptomics and proteomics, air-liquid interface co-culture.
- ActiveBiospecimen collection · Investigator-led studyInfectious disease
Influenza
Angela Phillips, PhD
Based in Microbiology & Immunology. Disease areas: Influenza.
- ActiveBiospecimen collection · BiobankAutoimmunity
Obesity and GLP-1 Biobank
Diana Alba, MD
Collects blood, fat tissue, and stool from diverse adults at Zuckerberg San Francisco General to study how obesity, GLP-1 drugs, and weight-loss surgery affect autoimmune and inflammatory diseases. Samples collected: Blood (serum, plasma, PBMCs), subcutaneous and visceral adipose tissue, stool, clinical and dietary questionnaires, dXA body composition.
- ActiveBiospecimen collection · Industry collaborationAutoimmunity
Tissue-Resident T Cells in Psoriatic Arthritis
Judith Ashouri, MD
Collects paired joint (synovial) tissue, skin, and blood from patients with psoriatic arthritis and spondyloarthritis to study tissue-resident memory T cells as a potential treatment target. Samples collected: Synovial tissue, skin biopsy, blood. Analyses: Multiplex immunofluorescence, flow cytometry. Participants: Adults with psoriatic arthritis or spondyloarthritis scheduled for a large-joint procedure.
- ActiveClinical trial · Phase 3 · Active, not recruitingLung disease
AIRTIVITY: BI 1291583 for Bronchiectasis
Shoshana Zha, MD, PhD
A Phase 3 trial testing whether a once-daily pill, BI 1291583, reduces flare-ups in adults and adolescents with bronchiectasis compared with placebo. Intervention: BI 1291583 2.5 mg tablet once daily vs. placebo, up to 76 weeks. Eligibility: Ages 12+ with CT-confirmed bronchiectasis, chronic sputum, and recent flare-ups needing antibiotics.
- ActiveClinical trial · Phase 2Lung disease
CLEAR: AZD0292 for Bronchiectasis with Pseudomonas
Shoshana Zha, MD, PhD
A Phase 2b trial testing AZD0292, an IV antibody treatment, to prevent flare-ups in people with bronchiectasis whose airways are chronically infected with Pseudomonas bacteria. Intervention: AZD0292 (bispecific monoclonal antibody), IV, two dose regimens vs. placebo. Eligibility: Ages 12+ (at least 35 kg) with CT-confirmed bronchiectasis, recent flare-ups, and chronic Pseudomonas in the airways.
- ActiveBiospecimen collection · Investigator-led studyCancer
Colorectal Cancer Organoids for Immunotherapy
Karin Pelka, PhD
Builds combined tumor and lymph-node organoids from colorectal cancer surgeries to test new immunotherapies, such as Treg depleters and CAR T cells, for the many colorectal cancers that don't respond to current immunotherapy. Samples collected: Fresh colectomy tumor, lymphoid tissue (lymph nodes / FNA), normal tissue. Analyses: Tumor organoids (ALI PDO), lymphoid organoids, xenium spatial profiling.
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