About the Project
Tuberculosis (TB), a disease triggered by the bacterium Mycobacterium tuberculosis, continues to be a major global health challenge. Remarkably, only about 5-10% of people exposed to the bacterium will develop active TB during their lives. This suggests that individual-specific factors play a crucial role in determining the risk of evolving from exposure to active disease. Factors influencing this risk include abnormalities in both innate and adaptive immune responses, metabolic imbalances, the presence of other infections or health conditions, and genetic variations that may increase susceptibility to TB. The Suliman research group aims to utilize systems biology methods, such as genome-wide association studies, transcriptional and metabolomic analysis, and the study of expression quantitative trait loci, to generate hypotheses. Their goal is to pinpoint potential pathways related to TB risk and conduct in-depth studies to understand how these pathways contribute to the development of the disease.
